The diversity of bone proteoglycan (PG) structure and localisation (pericellular, extracellular in the organic bone matrix) reflects a broad spectrum of biological functions within a unique tissue. PGs play important roles in organizing the bone extracellular matrix, taking part in the structuring of the tissue itself as active regulators of collagen fibrillogenesis. PGs also display selective patterns of reactivity with several constituents including cytokines and growth factors, such as transforming growth factor‐β or osteoprotegerin thereby modulating their bio‐availability and biological activity (...) in the bone tissue. In this review, the complex PG composition in bone will be addressed together with the specific role played by PGs (or their GAGs chains) in bone biology, as regulatory molecules for bone resorption and their involvement in bone tumor development. These roles have been determined after modulation of PG expression or mutations in their corresponding genes, which revealed specific roles for these compounds in bone pathologies (e.g. perlecan or glypican‐3 mutations observed respectively in chondrodysplasia or dysmorphic syndrome). Finally, the potential therapeutic interest of PGs is discussed based on recent data, more particularly on bone tumor‐associated osteolysis as these molecules are involved both in bone resorption and tumor development. BioEssays 29:758–771, 2007. © 2007 Wiley Periodicals, Inc. (shrink)

This study investigates how one important accounting professional authority—CPA Canada—discusses accounting ethics and exhorts its members to think about ethics-related issues. To do this, we rely on empirical evidence of the types of arguments used by CPA Canada to describe what they consider acceptable moral justifications in a variety of practical situations that accountants may encounter. We argue that the articles contained in the profession’s primary publication for all members, CPA Magazine, offer a wealth of such evidence. We analyze 237 (...) articles about accounting ethics that were published in CPA Magazine from January 2000 to December 2017, and find evidence of moral pluralism. Six categories of justifications dominate: private commitments, utility, perfectionist ends, general duties, and specific obligations, plus self-interest. Of these categories, the specific obligations logic is the most widely used. We offer a tentative explanation, and discuss the implications of our findings for a better grasp of the complexities of accountants’ practical conflicts and a rethink of the ongoing tension between professionalism and commercialism. (shrink)

Cet article souhaite porter un regard réflexif sur le projet scientifique de constitution et d’exploitation d’un grand corpus de français parlé, les Enquêtes sociolinguistiques à Orléans, né à l’aube de la sociolinguistique et qui se développe au tournant méthodologique et épistémologique des digital humanities. Quels objectifs? Quelles données? Quels traitements? Ce sont les questions qui guident la réflexion proposée ici afin d’apporter une contribution à l’élaboration de nouvelles pratiques scientifiques dans une perspective variationniste contemporaine.

In, Marker and Steinhorn characterized models of an o‐minimal theory such that all types over M realized in N are definable. In this article we characterize pairs of algebraically closed valued fields satisfying the same property. In o‐minimal theories, a pair of models for which all 1‐types over M realized in N are definable has already the desired property. Although it is true that if M is an algebraically closed valued field such that all 1‐types over M are definable then (...) all types over M are definable, we build a counterexample for the relative statement, i.e., we show for any that there is a pair of algebraically closed valued fields such that all n‐types over M realized in N are definable but there is an ‐type over M realized in N which is not definable. (shrink)

La brevetabilité du vivant suscite d’importantes questions car elle confronte le droit des brevets à certaines de ses limites comme, la non brevetablité des découvertes, l'interdiction d'appropriation du corps humain et la protection de l'intégrité du génome humain. Le présent article identifie ces limites et d'autres problématiques connexes, dans l'attente d'un article de fond plus complet sur le sujet.

La comparaison de deux corpus d’enquêtes sociolinguistiques réalisés à quarante ans d’intervalle permet de mettre en perspective certains aspects centraux de la constitution des données et d’interroger, par delà une description des différents choix méthodologiques et théoriques opérés, la place des données dans la linguistique de corpus.

La comparaison de deux corpus d’enquêtes sociolinguistiques réalisés à quarante ans d’intervalle permet de mettre en perspective certains aspects centraux de la constitution des données et d’interroger, par delà une description des différents choix méthodologiques et théoriques opérés, la place des données dans la linguistique de corpus.

Tri‐methylation of lysine 4 on histone H3 (H3K4me3) is a near‐universal chromatin modification at the transcription start site of active genes in eukaryotes from yeast to man and its levels reflect the amount of transcription. Because of this association, H3K4me3 is often described as an ‘activating’ histone modification and assumed to have an instructive role in the transcription of genes, but the field is lacking a conserved mechanism to support this view. The overwhelming finding from genome‐wide studies is that actually (...) very little transcription changes upon removal of most H3K4me3 under steady‐state or dynamically changing conditions, including at mammalian CpG island promoters. Instead, rather than a major role in instructing transcription, time‐resolved experiments provide more evidence supporting the deposition of H3K4me3 into chromatin as a result of transcription, influencing processes such as memory of previous states, transcriptional consistency between cells in a population and transcription termination. -/- . (shrink)

Début 1871, Helmholtz donne une conférence à Heidelberg, devant un public de non spécialistes, sur « la genèse du système planétaire », dont le sujet sera ce qu’il appelle la théorie de Kant-Laplace. Plutôt que de commencer par expliquer ce qu’il faut entendre par cette dernière, Helmholtz expose devant ses auditeurs la représentation que l’on se fait désormais de la formation des corps célestes et de leur devenir probable, en s’appuyant sur les progrès des connaissances, la découverte de nouvelles lois, (...) l’usage d’instruments de plus en plus perfectionnés. C’est ainsi que la validité de l’hypothèse de Kant et de Laplace se trouve confirmée a posteriori et leur audace légitimée. Aussi, la démarche adoptée par Helmholtz relativise-t-elle implicitement, et peut-être à son insu, la rigueur postulée de la bonne méthode scientifique. La cosmogonie esquissée par Helmholtz ressemble à un spectacle bien étudié dont les auditeurs sont les spectateurs, les savants, les acteurs, et la science épurée, l’enjeu. L’analyse de ce texte a donc pour objectif principal d’identifier et de rappeler les éléments contextuels qui lui confèrent son épaisseur, depuis la guerre franco-prussienne jusqu’aux tensions idéologiques, philosophiques, scientifiques qui en sont l’arrière-plan. (shrink)

Suddenly, COVID-19 has changed the world and the way people work. Companies had to accelerate something they knew was imminent in the future, but not immediate and extremely humongous. This situation poses a huge challenge for companies to survive and thrive in this complex business environment and for employees, who must adapt to this new way of working. An effective e-leadership, which promotes companies’ adaptability, is needed. This study investigates the existing knowledge on teleworking and e-leadership; and analyzes the supposed (...) challenges. The literature review shows that companies with effective e-leadership can view teleworking as an opportunity. It is advantageous for not only companies’ productivity but also the environment and people who work remotely. However, a traditional or no leadership can result in some risks. Thriving in remote work environments implies that managers must adjust the companies’ structure, making them less hierarchical, and developing new abilities to establish a strong and trustworthy relationship with their employees to maintain their competitiveness, while retaining a genuine concern for their employees’ well-being. Similarly, successful e-leadership must be able to consolidate and lead effective virtual teams to accomplish organizational goals. This study contributes to the literature and leaders during the pandemic. (shrink)

oise Baylis, 1234 Le Marchant Street, Halifax, Nova Scotia, Canada B3H 3P7. Tel.: (902)-494–2873; Fax: (902)-494-2924; Email: francoise.baylis{at}dal.ca ' + u + '@' + d + ' '//--> . Abstract Recently, there has been a growing interest in public health and public health ethics. Much of this interest has been tied to efforts to draw up national and international plans to deal with a global pandemic. It is common for these plans to state the importance of drawing upon a (...) well-developed ethics framework and we argue that this framework should reflect the values and insights of feminist relational theory. More specifically, we argue that pandemic planning must be squarely situated in the larger realm of public health and that an ethics framework for public health will be one that recognizes the need to pay particular attention to the vulnerability of subpopulations lacking in social and economic power. We propose an ethics framework for public health that builds on the notions of relational personhood (including relational autonomy and social justice) and relational solidarity. In this way, we aim for a public health ethics that, as appropriate, promotes the public interest and the common good. CiteULike Connotea Del.icio.us What's this? (shrink)

À partir de l'étude de la constitution et de l'histoire des archives du parlement de Paris et de leur traitement archivistique, ainsi que des multiples collections de copies et d'extraits dont elles ont été l'objet, cet article propose une réflexion sur la manière dont ce fonds d'archives, qui allie une exceptionnelle importance matérielle et historique et une particulière complexité, a pu être traité par les archivistes et utilisé par les chercheurs, ainsi que sur les perspectives qu'il peut ouvrir à la (...) recherche. Ces archives du Parlement illustrent en effet toute la gamme des problèmes de conservation, de traitement, de communication au public et d'exploitation et rendent particulièrement manifeste la complémentarité et l'interpénétration nécessaires, voire la confusion, des approches historique et archivistique ; elles démontrent que la connaissance par les chercheurs de l'histoire du fonds d'archives va bien au-delà de la simple pratique archivistique et contribue à la perception de la documentation comme« source» d'histoire. (shrink)

En partant de la définition des rituels, et notamment du rôle de la parole, qu'elle soit verbale ou non-verbale, cet article interroge la façon dont la ritualisation peut contribuer à l'éducation, notamment en milieu scolaire. Après un tour d'horizon des principaux aspects rituels de l'enseignement et de l'école, l'auteur questionne plus particulièrement les rituels d'apprentissage, c'est-à-dire ceux qui structurent la relation enseignant/enseigné au sein de la classe. En s'appuyant sur une théorisation psychanalytique elle montre alors comment les rituels peuvent ou (...) non, notamment en fonction de leur degré « d'ouverture », contribuer à faire exister les élèves dans leur singularité et, ce faisant, les aider à se construire dans leur rapport au savoir.Starting from the definition of rituals, including the role of speech, either verbal or non-verbal, this article examines how ritual can contribute to education, particularly in schools. After an overview of the main aspects of teaching and rituals of the school, especially the author questions the rituals of learning, that is to say those that structure the relationship teacher / learner in the class. Based on psychoanalytic theorizing it then shows how rituals may or may not, depending on their particular degree of "openness" to help students exist in their singularity, thereby helping to build in their relation to knowledge. (shrink)

This work was supported, in part, by a Stem Cell Network grant to Françoise Baylis and Jason Scott Robert and a CIHR grant to Françoise Baylis. We sincerely thank Alan Fine, Rich Campbell, Cynthia Cohen, and Tim Krahn for helpful comments on an earlier draft of this paper. Thanks are also owed to Tim Krahn for his research assistance. An earlier version of this paper was presented to the Department of Bioethics and the Novel Tech Ethics research team. We thank (...) the participants at each of these meetings for their helpful comments. (shrink)

Que voyons-nous? De joyeux enfants reprennent le chemin de l’école dans une rue spacieuse et ordonnée, mélange d’innocence et d’allégresse. Bien sûr, cette photographie – spontanée ou posée, peu importe – enjolive la réalité de l’URSS à ce moment donné de son histoire. Pourtant, par ses éléments constitutifs, les écoliers et le cadre, elle donne des indications intéressantes sur l’état de l’Union. Nous sommes à Moscou vers 1956. L’URSS vient de franchir une étape décisive après le XXe Congr...

In this article, I argue that there is no compelling therapeutic ‘need’ for human nuclear genome transfer to prevent mitochondrial diseases caused by mtDNA mutations. At most there is a strong interest in this technology on the part of some women and couples at risk of having children with mitochondrial disease, and perhaps also a ‘want’ on the part of some researchers who see the technology as a useful precedent – one that provides them with ‘a quiet way station’ in (...) which to refine the micromanipulations techniques essential for other human germline interventions and human cloning. In advance of this argument, I review basic information about mitochondrial disease and novel genetic strategies to prevent the transmission of mutated mitochondria. Next, I address common features of contemporary debates and discussions about so-called mitochondrial replacement. First, I contest the cliché that science-and-technology is fast outpacing ethics. Second, I dispute the accuracy of the term ‘mitochondrial replacement’. Third, I provide a sustained critique of the purported ‘need’ for genetically-related children. In closing, I call into question the mainly liberal defense of human nuclear genome transfer. I suggest an alternative frame of reference that pays particular attention to issues of social justice. I conclude that our limited resources should be carefully expended in pursuit of the common good, which does not include pandering to acquired desires. (shrink)

Fragments of painted plaster found in the destruction layer of three first floor rooms in the House of Seals and of one first floor room of the House of the Sword had broken from the ceiling. They allow the restoration of the schema in the room of the House of the Sword and of two of the rooms in the House of Seals, the latter in colour. Composed of bands surrounding a quadrangular field, these décorations, evoking carpets stretched on the (...) ceiling, are richer (costly pigments, gold leaf) and more complex (some fifteen motifs) than those in tombs of the same period, which adopted the same « carpet » composition and which borrowed from the same repertoire, often confirmed by the textiles. Since we know of no other ceiling decoration in habitation rooms, it is unwise to contrast the exuberance of these ceilings with the tomb ceilings. The room that could not be restored had moreover a much more perfunctory decoration. (shrink)

Les premières mythographies de l’Europe néo-latine, depuis la Genealogia deorum de Boccace, considèrent l’histoire des dieux sur le modèle des généalogies humaines, en cherchant à recomposer « la lignée de Saturne ». Les premiers historiens de la Grèce, comme les poètes, inventèrent des généalogies mythiques pour inscrire l’origine des hommes dans l’histoire de leur relation aux dieux. Que fondent les généalogies divines ? Non seulement des structures religieuses, non seulement la raison même des sociétés humaines, mais encore la préhistoire de (...) l’humanité. Mais si les engendrements divins donnent sens aux relations entre les hommes et les dieux, c’est l’histoire des commencements du monde que les mythographes cherchent à comprendre en interrogeant l’articulation des généalogies divines et humaines. Depuis que, dans le Timée, Platon a associé mythologia et genealogia comme deux modes de discours « archéologiques », les mythographes ont ouvertement revendiqué un savoir sur le monde qui se définit comme une synthèse des « sciences de la nature ».Mythologia, Genealogia, Archaiologia:A Paleontological Scope for Mythography. The first European mythographical treatises in the Middle Ages and Renaissance, since Boccaccio’s Genealogia deorum, were determined by a genealogical method, looking at the history of the gods with human patterns and seeking the reconstruction of “Saturn’s lineage”. The early Greek mythographers, like the poets, imagined various genealogies for seeking out the origins of humanity through their relationships with gods. What is founded on divine genealogies? Not only religious structures, nor only the true ratio of human sociability, but a human paleon­tology too. By interpreting filiations as a system of connexions between gods and humans, the mythographers aimed at understanding the protohistory of the universe. Since Plato’s Timaeus associated mythologia and genealogia as two modes of “archaeological” discourse, mythographers have wanted to assert their own “physical science” as a whole synthetic perception of the natural world. (shrink)

We need to distinguish two sorts of natural kinds, scientific and common NKs, because the notion of NK, which has to satisfy demands at three different levels—ontological, semantic and epistemological—, is subject to two incompatible sets of constraints. In order to prove this, I focus on the much-discussed case of jade. In the first part of the paper, I show that the current accounts are unsatisfactory because they are inconsistent. In the process, I explain why LaPorte’s analysis of “jade” as (...) a vernacular NK-term with an open-texture meaning does not offer a way out. Using a reductio ad absurdum argument, I conclude that according to the main tenets of NK-term theories, today’s “jade” has to be an NK-term, and jade thereby an NK. In the second part of the paper, I argue for this conclusion in a positive manner. First, I present a series of thought experiments demonstrating that today’s “jade” has the specific features of an NK-term. Then, I show that the kind that we presently call “jade” exhibits the typical ontological and epistemological features of an NK. More generally, I expound on why common NKs are more than mere classes, and why categories such as “jade” are useful in many inferences and explanations. (shrink)

L’article procède à un cheminement en quatre étapes : la première traite de la question de la mesure économique des productions nanométriques, dans une dynamique de filière et de convergence multidisciplinaire, champ d’étude de la méso-économie ; la seconde fait référence aux origines de l’approche mercantiliste de l’économie et à ses conséquences sur l’économie politique des matériaux avancés, procédés et services du domaine des nanotechnologies et matériaux avancés manufacturés ; la troisième étape recherchera les points d’appui sur lesquels l’économie politique (...) fait porter ses efforts pour développer la production et les échanges induits par les nanosciences et techniques en s’appuyant sur deux exemples ; la quatrième et dernière étape examine les barrières réelles au développement économique induit par les nanotechnologies, telles que les conflits d’intérêts entre acteurs autour de la question de la traçabilité les ont progressivement révélées dans les dialogues entre parties prenantes. (shrink)

A totally ordered group G is essentially periodic if for every definable non-trivial convex subgroup H of G every definable subset of G is equal to a finite union of cosets of subgroups of G on some interval containing an end segment of H; it is coset-minimal if all definable subsets are equal to a finite union of cosets, intersected with intervals. We study definable sets and functions in such groups, and relate them to the quasi-o-minimal groups introduced in Belegradek (...) et al. . Main results: An essentially periodic group G is abelian; if G is discrete, then definable functions in one variable are ultimately piecewise linear. A group such that every model elementarily equivalent to it is coset-minimal is quasi-o-minimal , and its definable functions in one variable are piecewise linear. (shrink)

Given a simple non-trivial finite-dimensional Lie algebra L, fields $K_i$ and Chevalley groups $L(K_i)$ , we first prove that $\Pi_{\mathcal{U}} L(K_i)$ is isomorphic to $L(\Pi_{\mathcal{U}}K_i)$ . Then we consider the case of Chevalley groups of twisted type ${}^n\!L$ . We obtain a result analogous to the previous one. Given perfect fields $K_i$ having the property that any element is either a square or the opposite of a square and Chevalley groups ${}^n\!L(K_i)$ , then $\pu{}^n\!L(K_i)$ is isomorphic to ${}^n\!L(\pu K_i)$ . (...) We apply our results to prove the decidability of the set of sentences true in almost all finite groups of the form L(K) where K is a finite field and L a fixed untwisted Chevalley type. (shrink)

Now that stem cell scientists are clamouring for human eggs for cloning-based stem cell research, there is vigorous debate about the ethics of paying women for their eggs. Generally speaking, some claim that women should be paid a fair wage for their reproductive labour or tissues, while others argue against the further commodification of reproductive labour or tissues and worry about voluntariness among potential egg providers. Siding mainly with those who believe that women should be financially compensated for providing eggs (...) for research, the new stem cell guidelines of the International Society for Stem Cell Research (ISSCR) legitimise both reimbursement of direct expenses and financial compensation for many women who supply eggs for research. In this paper, the authors do not attempt to resolve the thorny issue of whether payment for eggs used in human embryonic stem cell research is ethically legitimate. Rather, they want to show specifically that the ISSCR recommended payment practices are deeply flawed and, more generally, that all payment schemes that aim to avoid undue inducement of women risk the global exploitation of economically disadvantaged women. (shrink)

Given a model-complete theory of topological fields, we considered its generic differential expansions and under a certain hypothesis of largeness, we axiomatised the class of existentially closed ones. Here we show that a density result for definable types over definably closed subsets in such differential topological fields. Then we show two transfer results, one on the VC-density and the other one, on the combinatorial property NTP2.

Most philosophers adopt an etiological conception of functions, but not one that uniformly explains the functions attributed to material entities irrespective of whether they are natural or man-made. Here, I investigate the widespread idea that a combination of the two current etiological theories, SEL and INT, can offer a satisfactory account of the proper functions of both organisms and artifacts.. Making explicit what a realist theory of function supposes, I first show that SEL offers a realist theory of biological functions (...) in which these are objective properties of a peculiar sort. I argue next that an artifact function demonstrates the same objective nature as a biological function when it is accounted for by SEL, but not when it is accounted for by INT. I explain why a dual theory of artifact functions admitting both INT and SEL functions is to be dismissed. I establish that neither INT nor SEL alone can account for all artifact functions. Drawing the conclusion that we need a new etiological theory of function, I show how one can overcome the apparent inevitability of INT for some artifact functions. Finally, I outline a new etiological theory of functions that applies equally to biological entities and to artifacts. (shrink)

The existence of dysfunctions precludes the possibility of identifying the function to do F with the capacity to do F. Nevertheless, we continuously infer capacities from functions. For this and other reasons stated in the first part of this article, I propose a new theory of functions (of the etiological sort), applying to organisms as well as to artefacts, in which to have some determinate probability P to do F (i.e. a probabilistic capacity to do F) is a necessary condition (...) for having the function to do F. The main objective of this paper is to justify the legitimacy of this condition when considering artefacts. I begin by distinguishing “perspectival probabilities”, which reflect a pragmatic interest or an arbitrary state of knowledge, from “objective probabilities”, which depend on some objective feature of the envisageditems. I show that objective probabilities are not necessarily based on physical constitution. I then explain why we should distinguish between considering an object as a physical body and considering it as an artefact, and why the probability of dysfunction to be taken into account is one relative to the object as member of an artefact category. After clarifying how an artefact category can be defined if it is not defined in physical terms, I establish the objectivity of the probability of dysfunction under consideration by showing how it is causally determined by objective factors regulating the production of items of a definite artefact type. Ifocus on the case of industrially produced artefacts where the objective factors determining the probability of dysfunction can be best seen. (shrink)

We describe classes of existentially closed ordered difference fields and rings. We show an Ax-Kochen type result for a class of valued ordered difference fields.